Glycan Arrays

GlycoUniverse offers Glycan Microarray service to help researchers to screen glycan-binding interactions. Our exclusive and built-to-order library of Glycan Standards includes diverse oligosaccharide sequences of mammalian glycoproteins, glycolipids, glycosaminoglycans as well as those from bacterial, fungal and plant polysaccharides. Broad-spectrum and focused arrays, including Lectin arrays, Mucin arrays, Siglec ligands arrays, Human-milk oligosaccharide (HMO) arrays, Tumor-associated carbohydrate antigens (TACAs) arrays, can be screened in parallel.

Illustrative Example: A comprehensive profile of an individual's serum antiglycan antibodies was obtained using 5 mL of serum and a glycan microarray containing 220 features robotically spotted onto a glass slide. Analogous to protein antigen arrays, captured antibodies were labeled with fluorescent secondary antibodies, and scanning quantified the amount of IgM, IgG, or total immunoglobulin bound to each glycan. Reference: Campbell et al. DOI: 10.1158/1078-0432.CCR-12-2478